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A human brain is shown attached to the top part of the spinal cord. Thin nerves are coming out of the spinal cord.
Figure 10.1 The nervous system, the body’s control center, consists of the brain, the spinal cord, and a complex system of nerves. (attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license)

The peripheral nervous system (PNS) is divided into two main subdivisions: the somatic motor system and the autonomic nervous system (ANS). The somatic nervous system controls voluntary muscle movement, and the autonomic nervous system is responsible for regulating numerous involuntary functions, such as the heart, secretory glands, and smooth muscle. The ANS is further divided into the parasympathetic nervous system (PSNS) and sympathetic nervous system (SNS) (see Figure 10.2). The PSNS relaxes the body and maintains certain life-sustaining properties such as digestion and excretion. The SNS is involved in the fight-or-flight response by preparing the body to deal with stressors. There are two primary types of receptors within the PNS: cholinergic receptors and adrenergic receptors. Cholinergic receptors are activated by the neurotransmitter acetylcholine (ACh) and can be activated by endogenous or exogenous substances. Adrenergic receptors are stimulated by the neurotransmitter norepinephrine (Bekdash, 2021). In addition, these primary receptors have subtypes.

A diagram of the human body highlights the organs and spinal column associated with the parasympathetic and sympathetic nervous system. The parasympathetic nervous system constricts pupils, stimulates salivation, constricts bronchi, slows heart rate, stimulates bile production, stimulates digestion, and causes an erection. The sympathetic nervous system dilates pupils, inhibits salivation, relaxes bronchi, increases heart rate, slows digestion, stimulates glucose release, relaxes intestinal muscles, produces adrenaline, and promotes ejaculation.
Figure 10.2 The autonomic nervous system consists of the parasympathetic nervous system (PSNS) and the sympathetic nervous system (SNS). The PSNS relaxes the body and maintains certain life-sustaining properties. The SNS is involved in the fight-or-flight response. (attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license)

This chapter will focus on only the cholinergic receptors with no further discussion of adrenergic receptors. There are three major subtypes of cholinergic receptors: muscarinic, nicotinicM, and nicotinicN. Table 10.1 describes the functions of each of these. In some organs, the PSNS and SNS work in opposition to each other (such as increasing or decreasing the heart rate). In other organs, the two systems have a complementary effect where both divisions are necessary for a physiological function to occur; for example, the PSNS is involved in males obtaining an erection, and the SNS is responsible for ejaculation. Both systems are required to work together for reproduction to successfully take place.

Notably, cholinergic receptors are not associated with the nervous system in any way. Regardless, the cholinergic receptors on blood vessels do have pharmacologic efficacy because drugs that are able to activate these receptors will cause blood pressure to decrease.

Receptor Type Function
Muscarinic
  • Promotes increased glandular secretions from pulmonary, gastric, intestinal, and sweat glands
  • Causes contraction of smooth muscle in the bronchi and increase bronchial secretions
Nicotinic Muscle
  • Causes contraction of skeletal muscle
Neuronal
  • Stimulates ganglionic transmission at all ganglia of the SNS and PSNS
  • Promotes release of epinephrine from the adrenal medulla
Table 10.1 Functions of Acetylcholine at Cholinergic Receptor Subtypes
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