Why does the human body need more than its skin to function as a barrier to infecting pathogens?
Skin works only against some types of bacteria. To prevent the entry of other pathogens, other physical or chemical barriers are needed.
Skin does not provide a broad coverage against invasion of the body by any foreign particle, so it is not a very effective barrier.
Pathogens could enter the body through several places that are not covered by skin that need to have a barrier to prevent infection.
Skin acts only as a chemical barrier against pathogens. The body also needs physical barriers to prevent various types of infection.
30.
Cell surface recognition occurs during many types of immune responses, including immediate and induced immune responses. How do natural killer cells and interferons represent one of each type of immune response (immediate and induced), and how does cell surface recognition play a role?
Natural killer cells are an example of induced immune response as they attack host cells that have lost normal cell surface markers. Interferons are an example of immediate immune response as they are induced after cell surface markers on invading pathogens are recognized by host cells.
Natural killer cells are an example of immediate immune response as they attack host cells that have lost normal cell surface markers. Interferons are an example of induced immune response as they are induced after cell surface markers on invading pathogens are recognized by host cells.
Natural killer cells are an example of immediate immune response as they are induced after cell surface markers on invading pathogens are recognized by host cells. Interferons are an example of induced immune response as they attack host cells that have lost normal cell surface markers.
Natural killer cells are an example of induced immune response as they are induced after cell surface markers on invading pathogens are recognized by host cells. Interferons are an example of immediate immune response as they attack host cells that have lost normal cell surface markers.
31.
Why might different MHC I molecules between donor and recipient cells lead to rejection of a transplanted organ or tissue?
The natural killer cells in the recipient will identify the MHC I molecules on transplanted organ as non-self proteins, causing lysis of transplanted cells. Other host cells will join to phagocytize the foreign cells.
The neutrophils in the recipient will identify the MHC I molecules on transplanted organ as non-self proteins, causing lysis of transplanted cells. Other host cells will join to phagocytize the foreign cells.
B lymphocytes in the recipient will identify the MHC I molecules on transplanted organ as non-self proteins. The foreign cells will then be engulfed and destroyed by B lymphocytes.
The macrophages in the recipient will identify the MHC I molecules on transplanted organ as non-self proteins, causing lysis of transplanted cells. Other host cells will join to phagocytize the foreign cells.
32.
Suppose a person was born without the ability to produce MHC I molecules. What problem would that create?
A person without the ability to produce MHC I molecules would die immediately.
A person without the ability to produce MHC I molecules would recognize self as non-self, resulting in autoimmune disease.
The person’s immune system would not be able to distinguish self and non-self. This would make the person very vulnerable to infection.
The person’s immune system would not be able to destroy foreign pathogen due to lack of hydrolytic enzymes. This would make the person very vulnerable to infection.
The image shows how the complement system can bind to and destroys a pathogen.
Suppose a genetic mutation prevented C2 and C4 proteins from being built properly. Would the entire complement system be compromised? Why or why not?
No, because the complement system functions as a cascade, with each protein triggering the activity of the next protein in the cascade.
Yes, because the complement system functions as a cascade, with each protein triggering the activity of the next protein in the cascade.
Yes, because all the proteins of the complement system function independently.
No, because all the proteins of the complement system function independently.
34.
What is a likely reason to explain why vertebrate animals evolved an adaptive immune system rather than an innate system involving specific responses to specific pathogens?
An adaptive immune system requires an immense amount of information to be stored, which allows vertebrate cells to be able to mount specific responses to every pathogen.
As new pathogens evolve all the time, it is more conservative of energy and information storage to have an adaptive immune system that can respond to same pathogens in different ways.
As new pathogens evolve all the time, it is more conservative of energy and information storage to have an adaptive immune system that can respond to different pathogens in a specific way.
As new pathogens evolve all the time, it is more conservative of energy and information storage to have an adaptive immune system that can respond to different pathogens in a non-specific way.
35.
Invertebrate animals have innate immune systems and lack adaptive immune systems. Vertebrates, including fish, amphibians, reptiles, birds, and mammals have both systems.
Based on this information, make a claim about evolution of these two immune systems.
The innate immune system evolved first. The adaptive immune system developed after Invertebrates and vertebrates diverged. In vertebrates, the adaptive immune system evolved relatively early.
The adaptive immune system evolved first. The innate immune system developed after Invertebrates and vertebrates diverged. In vertebrates, the adaptive immune system evolved relatively early.
The innate immune system evolved first. In vertebrates, the adaptive immune system evolved multiple times in different lineages.
The adaptive immune system evolved first. In vertebrates, the innate immune system evolved multiple times in different lineages.
36.
What are naïve B or T cells and how do they function in cell-mediated and humoral immune responses?
Naïve B and T cells are lymphocytes of the B and T types that have come into contact with pathogenic antigens. Naïve T cells produce antibodies in the humoral immune response, while naïve B cells stimulate the cell-mediated immune response.
Naïve B and T cells are lymphocytes of the B and T types that normally circulate in the body at all times and have not come into contact with any pathogenic antigens. Activated T cells produce antibodies in the humoral immune response, while activated B cells stimulate the cell-mediated immune response.
Naïve B and T cells are lymphocytes of the B and T types that normally circulate in the body at all times and have not come into contact with any pathogenic antigens. Activated B cells produce antibodies in the humoral immune response, while activated T cells stimulate the cell-mediated immune response.
Naïve B and T cells are lymphocytes of the B and T types that have come into contact with pathogenic antigens. Naïve B cells produce antibodies in the humoral immune response, while naïve T cells stimulate the cell-mediated immune response.
37.
A person given a flu vaccine in November comes down with a severe case of influenza in January. What can you conclude about the flu vaccine and cross reactivity?
The flu vaccine elicited antibodies in the person’s body that were specific to a particular flu virus. Unfortunately, the flu virus that infected the person later in January was different enough for cross reactivity to occur between the virus antigens causing the infection.
The flu vaccine suppresses antibodies in the person’s body that were specific to a particular flu virus. Unfortunately, the flu virus that infected the person later in January was different enough for cross reactivity to occur between the virus antigens causing the infection.
The flu vaccine suppresses antibodies in the person’s body that were specific to a particular flu virus. Unfortunately, the flu virus that infected the person later in January was similar enough for cross reactivity to occur between the virus antigens causing the infection.
The flu vaccine suppresses antibodies in the person’s body that were specific to a particular flu virus. Unfortunately, the flu virus that infected the person later in January was similar enough for cross reactivity to occur between the virus antigens causing the infection.
38.
What function does the diversity of the variable region of an antibody help it perform?
It helps in communication of antibodies with other components of immune system.
It helps the antibodies to function with very low affinity and specificity.
It enables many different antibodies to be made that all have different specificities of binding.
It enables many different antibodies to be made that all have same specificities of binding.
39.
How can you explain that the same antibodies found in an infant’s body after birth are also present in the infant’s mother?
Antibodies produced in the mother’s body are passed to the infant via passive immunity through breast milk.
Antibodies produced in the mother’s body are passed to the infant via active immunity through breast milk.
Antibodies produced in the mother’s body are passed to the infant via passive immunity through the placenta.
Antibodies produced in the infant’s body are passed to the mother through the placenta.
40.
Researchers have been working on developing methods for stimulating the human immune system to recognize foreign proteins as self proteins. Why would this research be applicable to treating allergies?
In an allergy, a person’s immune system has been compromised, which causes unpleasant symptoms.
In an allergy, a person’s immune system reacts to its own proteins, which causes unpleasant symptoms.
In an allergy, a person’s immune system reacts to a harmless protein from the environment, which causes unpleasant symptoms.
In an allergy, a person’s immune system reacts to a harmless protein from the environment, which causes pleasant symptoms.
41.
A patient has just been informed that they have an autoimmune disease that attacks the salivary glands. How would you explain to the patient what is happening inside their body?
The immune system is producing antibodies against their own proteins present in their salivary glands, causing the salivary glands to break down and become non-functional.
The ability of the immune system to fight the antigen present in the salivary glands might have been compromised, causing the salivary glands to break down and become non-functional.
The immune system might have reacted in an abnormal way to an antigen that may have entered salivary glands, causing the salivary glands to break down and become non-functional.
Some pathogen might have entered the salivary glands, causing the salivary glands to break down and become non-functional.
42.
(credit: modification of work by Baldo B.A., Pham N.H./Drug Allergy)
Figure 33.33
This graph shows how well the lungs function result in an allergic patient following exposure to an allergen.
What is a likely claim that can be done based on this graph?
Lung function suffers an immediate decrease and then gradually recovers.
Lung function suffers a gradual decrease in the next 20 hours.
Lung function suffers an immediate decrease, recovers and then suffers a secondary, more serious decrease some hours later.
Lung function suffers an immediate decrease, recovers and then suffers a secondary, less serious decrease some hours later.
(credit: modification of work by Baldo B.A., Pham N.H./Drug Allergy)