Breathing is an involuntary event. How often a breath is taken and how much air is inhaled or exhaled are tightly regulated by the respiratory center in the brain. Humans, when they aren’t exerting themselves, breathe approximately 15 times per minute on average. Canines, like the dog in Figure 30.1, have a respiratory rate of about 15–30 breaths per minute. In addition to exhaling carbon dioxide when we breathe, scientists believe people with cancerous lung cells also exhale tiny amounts of volatile organic compounds. Researchers used specially trained dogs to see if they could tell the difference between people with and without lung cancer. The dogs correctly identified 71 out of 100 lung cancer patients and 372 out of 400 who did not. You can read more about this exciting research here.