21.2 Factors Affecting Skin Integrity

Impetigo

Most commonly found in children, impetigo is a highly contagious superficial skin infection. Patients with impetigo can spread it to other areas of their own body as well as to other people they come in contact with. Although it can occur anywhere on the body, it primarily occurs on the arms, legs, and face. Impetigo is either bullous or nonbullous in nature. Usually sporadic, bullous impetigo develops on intact skin and is caused by Staphylococcus aureus. Flaccid bullae generally grow in size to form larger blisters filled with clear yellow to dark turbid fluid and burst to expose raw skin that becomes covered with a thin brown crust. The most common kind of impetigo is nonbullous impetigo that usually occurs after injury to the skin or as a secondary bacterial infection of another skin disorder like atopic dermatitis. Nonbullous impetigo presents as clusters of pustules that rapidly break down and form thick, adherent, honey-colored crusts on the face and extremities. Other risk factors for impetigo include poor hygiene and a moist environment. Treatment for impetigo may include topical or oral antibiotics.

Often called deep impetigo, ecthyma is a skin infection that occurs deep inside the skin characterized by shallow, small ulcers that look punched-out and may contain pus. The brown crust that covers the ulcers is thicker than the crust that covers the ulcers of impetigo. Treatment options for impetigo and ecthyma include antibiotic ointments or creams for smaller areas. Larger infected areas or areas that are not responding to the topical antibiotics may require oral antibiotics. The infected areas should be washed gently with soap and water multiple times a day to remove crusts. Individuals who have recurrent infections should have a nasal swab cultured to see if they are a nasal carrier of Staphylococcus or Streptococcus. People who are nasal carriers will need a topical antibiotic applied to their nasal passages (Rehmus, 2023).

Folliculitis

An infection of the hair follicle that often results from occluded hair follicles is termed folliculitis. It may affect a single hair follicle or multiple hair follicles. Common risk factors for folliculitis include poor hygiene, maceration (occurs when skin is exposed to a moist environment for too long), occlusive emollient products, and contact with contaminated water. Folliculitis often appears as pustules surrounded by erythema where a hair follicle is present. Hair follicles may easily fall out as well. Treatment includes warm compresses after washing with antibacterial soap and water multiple times a day, topical antibiotics, and oral antibiotics.

Carbuncle

A carbuncle is a skin abscess that connects with other carbuncles below the surface of the skin to form clusters, often forming when one or more hair follicles become infected. If left untreated, the abscesses fill with pus and will rupture, discharging a creamy pink or white fluid. If the abscess is too deep, it may not be able to drain on its own. Bacteria can spread from the abscess and infect surrounding tissues and lymph nodes. Infected individuals may also have a fever, chills, and malaise. Carbuncles are likely to leave a scar. Most carbuncles are caused by Staphylococcus aureus. Risk factors for the development of carbuncles include poor overall health, friction from shaving or clothing, and poor hygiene. Patients with weakened immune systems are more likely to develop Staphylococcus infections that lead to carbuncles. Some skin abscesses may go away on their own with the use of warm compresses. However, some carbuncles may require a provider to open and drain the abscess and then wash out the pocket with a sterile saline solution. Oral antibiotics may also be needed to aid in treating the infection. Individuals with recurrent skin abscesses may be instructed to wash their skin with antiseptic solutions (e.g., iodine) (Rehmus, 2023).

Cellulitis

A localized infection and inflammation of the skin and tissues beneath the skin is called cellulitis. It is most often caused by Streptococcus, Staphylococcus, and Methicillin-resistant Staphylococcus aureus. The infection usually occurs when the bacteria enters open wounds, skin abscesses, fungal infections, or other skin conditions. Although cellulitis can occur anywhere on the body, it occurs most often on the legs and affects one side of the body. Bilateral cellulitis is rare, and its presence should warrant assessment of other health conditions (Chuang et al., 2022).

The infection generally presents with redness, tenderness, and pain. The skin also often becomes hot and swollen and may look slightly pitted. A fluid-filled vesicle (small blister) or a bulla (large blister) may appear on the infected areas. Some patients may experience fever, rapid heart rate, headache, confusion, hypotension, or chills. If the infection spreads to the lymph nodes, the nodes can become tender and swollen, and the vessels can become inflamed. Treatment may include antibiotics, drainage of any abscesses, and treatment of any disorders contributing to the infection (Rehmus, 2023). Compression stockings (thromboembolic deterrent [TED] hose) may also be effective by reducing edema (swelling caused by excessive buildup of fluid in tissue spaces or a body cavity) and increasing blood flow.

Herpes Simplex

A viral infection that can cause painful blisters or ulcers is herpes simplex and is categorized into herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2). Most often, HSV-1 spreads by oral contact and causes infections in or around the mouth or lips. This virus presents as ulcers or blisters (cold sores). It can also cause genital herpes if an infected person made contact with another person’s genital mucosa. HSV-1 is commonly spread through kissing, sharing objects that are in or near the mouth, and any other skin-to-skin contact. On the other hand, HSV-2 is spread by sexual contact and causes genital herpes. This virus usually presents as open sores, blisters, or bumps around the anus or genitals. It may also appear in the sacral area. Someone who has an active outbreak and is giving birth can also pass the virus to the baby.

It is not uncommon for patients with herpes infections to have little to no symptoms; therefore, an infected individual may unknowingly spread the virus. The first outbreak may be accompanied by body aches, swollen lymph nodes, and fever. Subsequent outbreaks may begin with burning, itching, or tingling prior to the appearance of blisters. The blisters often appear in clusters and break open, ooze, and crust over. Outbreaks can be caused by triggers like stress, fever, illness, surgery, menstrual periods, and sun exposure. This virus can be recurring and is not curable. Antiviral medications (e.g., valacyclovir [Valtrex] and acyclovir [Zovirax]) may be used to shorten the length and severity of the herpes simplex breakout. Some patients may take the medications daily to prevent outbreaks and lessen the chance of spreading it to others. Other treatment options include minimizing triggers, topical anesthetics, topical ointments, or over-the-counter pain medications like acetaminophen (Tylenol) or ibuprofen (Motrin). Patients with genital herpes may decrease symptoms by wearing loose clothing and sitting in a warm bath without soap. Cold drinks or popsicles may also aid in providing relief to those with oral cold sores. Patients should also be educated on the importance of informing any potential sexual partners and abstaining from sexual activity when lesions are present, replacing toothbrushes or lip balms used during the presence of a cold sore, and not sharing utensils or drinks with uninfected people (World Health Organization, 2023).

Herpes Zoster

The varicella (chickenpox) infection is caused by the varicella-zoster virus. After the initial illness has ended, the virus remains dormant in the dorsal root ganglia and can reactivate later in the person’s life causing a painful, maculopapular rash called herpes zoster (shingles). Patients who have received a varicella vaccine are also at risk of developing herpes zoster later. The rash associated with shingles most often appears on the trunk of the body along a thoracic dermatome. The rash primarily stays on one side of the body, follows dermatomes, and does not cross the midline. Although not common, the rash can affect three or more dermatomes and is called disseminated zoster. This type of rash occurs in patients with a weakened or suppressed immune system. The symptoms are often painful, tingly, or itchy and may precede the appearance of the rash. Some patients may also experience headache, malaise (overall weakness) in the prodromal state (period between the appearance of initial symptoms and the full development of an illness), chills, or photophobia (bright light sensitivity). Vesicles develop into clusters, which continue to form over three to five days and gradually dry and crust over. The rash usually heals in two to four weeks and can leave scarring or pigmentation changes behind. Shingles can be prevented by the recombinant zoster vaccine. This virus can spread to others when it is active and can cause varicella in those who have never had varicella or been vaccinated against it. Antiviral medications, like valacyclovir and acyclovir, may also be used to shorten the length and severity of a shingles breakout (Centers for Disease Control and Prevention, n.d.).

Verruca

A growth on the skin caused by the viral infection human papillomavirus (HPV) is called a verruca or a wart. The warts may appear raised or flat and can have a black dot in the middle. Warts are often not painful, although some people may complain of pain. Warts may develop at any age but are more commonly found in children. Patients with warts may have as few as one or as many as hundreds. Warts are contagious and can spread from one area of the patient’s body to another body part or to another person through prolonged or repeated contact. Only a small break in the skin needs to be present for the virus to spread (Dinulos, 2023c). Genital warts, however, are spread by sexual contact.

Verrucae are classified by their shape and location. A warts that grows in clusters is referred to as a mosaic wart. Common warts are firm, round, or irregularly shaped growths with a rough surface. They may be brown, yellow, gray-black, or light gray and are generally less than 1 centimeter across. These warts appear on the face, fingers, elbows, and knees. A wart on the soles of the feet is a plantar wart and is usually flat due to the pressure of standing and walking. Warts that appear on the soles of the feet may cause pain when walking or standing. A wart found on the palms of the hand is a palmar wart. Both palmar and plantar warts tend to be hard and flat with well-defined boundaries and a rough surface. Thick, cauliflower-like growths around the fingers are known as periungual warts. A long, small, narrow growth that appears on the lips, face, or eyelids is a filiform wart. A warts that may appear in areas that are shaved or along stretch marks is a flat wart. They are typically smooth, flat topped, and either yellow-brown, pink, or flesh colored. A warts that occurs on the vagina, vulva, cervix, and penis is a genital wart (condyloma acuminata, venereal warts). This type of wart can be flat, smooth, and irregular or velvety bumpy growths with a cauliflower-like texture (Dinulos, 2023c).

Generally, warts are easily recognizable by appearance. Occasionally, a biopsy may be needed to confirm the diagnosis. Treatment options include applying topical chemicals and burning, cutting, or freezing the wart. A candidal yeast antigen may be injected into the warts causing an immune response to fight against the virus (Dinulos, 2023c). Warts may return even after removal. The human papillomavirus (HPV) vaccine may be used to prevent the spread of the virus. Patients with genital warts should have the warts removed to prevent spreading from person to person. They should also be educated on safe sex and the need to inform their partners of the diagnosis.

Tinea

Also known as ringworm, tinea may be found on the feet, beard, body, groin, scalp, or toes. The condition tinea pedis (or athlete’s foot) is characterized by a buildup of scale and may be accompanied by redness and itching. This infection is commonly caused by sweat from the feet accumulating between the toes allowing fungi to grow. This infection can spread to others who share showers, bathrooms, or other areas where infected individuals walk barefoot. Patients who wear tight shoes are also at risk of developing this infection. Fluid-filled blisters may also form with this infection. If the scaling is severe, the skin may crack and can lead to bacterial infections. Athlete’s foot may be treated by topical antifungal ointments or oral antifungals like itraconazole (Sporanox). Prevention measures include wearing sandals or shower shoes in communal bathrooms, wearing breathable shoes, frequently changing socks, minimizing moisture on feet and in footwear, and completely drying feet and in between toes after bathing. Antifungal powders may also be used to aid in keeping the feet dry (Aaron, 2023).

A tinea barbae (beard ringworm) infection is generally superficial but may occur deeper into the dermis. Tinea barbae is characterized by circular patches or a swollen patch that may ooze pus and can result in scarring or whisker loss. Most beard skin infections are caused by bacteria rather than fungi; however, tinea barbae is a fungal infection. Antifungal medications or corticosteroids are common treatments for beard ringworm (Aaron, 2023).

The fungal skin infection tinea corporis (body ringworm) affects the face, arms, trunk, and legs. This infection is characterized by round, pink-to-red patches with raised, scaly borders that can be itchy. Clearing in the center may also be present. This infection can spread from one area of an infected person’s body to another or from person-to-person contact. Antifungal medications may be applied topically or taken orally to treat this infection (Aaron, 2023).

A tinea cruris (jock itch) infection is a fungal skin infection of the groin. This is often characterized by a painful, itchy rash with a scaly, pink border. This infection is more common in men and is caused by trapped moisture between the scrotum and thigh and most often develops in warm weather or when wearing tight or wet clothing. Patients of a higher weight are at risk as well because of trapped moisture in skinfolds. The infection usually begins in the skinfolds of the genital area and spreads to the upper inner thighs. Antifungal medications may be taken orally or applied topically (Aaron, 2023).

The fungal infection tinea capitis (scalp ringworm) occurs on the scalp. This infection is characterized by a scaly, dry patch, a patch of hair loss, or both. The hair shafts may break at the surface (black dot ringworm) or break above the surface (gray patch ringworm). This infection can also cause dandruff-like flaking. A kerion may also be present. A kerion is a large, inflamed, swollen and sometimes painful patch that can ooze pus. A culture may be needed to assess the type of fungus, or a UV light may be used to confirm the diagnosis. Treatment of scalp ringworm includes oral antifungals, antifungal creams, selenium sulfide (Selsun Blue) shampoos, or corticosteroids (Aaron, 2023).

The fungal infection tinea unguium involves the toenail or fingernail. This infection is characterized by thickened nails that crumble easily and have white or yellow discoloration. The whole nail may become detached in more severe infections. If left untreated, the patient may have pain, balance issues, or a candidal infection. Treatment options include oral antifungals, topical ciclopirox olamine (Penlac) nail lacquer, and topical antifungals. Prevention is similar to that of preventing athlete’s foot.

Scabies

The Sarcoptes scabiei mite causes scabies. Scabies are accompanied by extreme itching, no matter how few mites have burrowed into the skin. Initially, the burrows are often visible and can be anywhere on the body, except they are less likely on the face. The burrows appear as a thin line and can have a tiny bump where the mite is located. Darker-skinned individuals may only display raised, solid areas. Due to the intense scratching, this infestation can often turn into a bacterial infection. Over time, the areas usually become inflamed, making the burrows less visible. Infestations that turn severe may cause areas of crusted, thickened skin that do not itch. Risk factors for attracting scabies are crowded conditions like schools, multifamily homes, and shelters. Hygiene is not a factor with scabies.

Treatment for scabies includes applying topical permethrin (Acticin) creams or lindane (Lindane) lotions to the skin for several hours before washing off. Lindane lotion is contraindicated in children under the age of 2 years, patients with a seizure disorder, and pregnant or breastfeeding patients. For older children and adult patients, spinosad suspension (Natroba) may be applied to the skin avoiding the eye. Ivermectin (Stromectol) may also be taken orally for people who have not had therapeutic benefits from topical medications or cannot use them. Itching can be relieved by oral and topical antihistamines. Infestations that progress to a bacterial infection may also require antibiotics. Physical objects that have come in contact with an infested patient should be washed in hot water, thoroughly dried on high heat, and stored in a sealed plastic bag for three days. Individuals who have close contact with a patient experiencing an infestation should also be treated (Dinulos, 2023a).

Pediculosis

A lice infestation is pediculosis. Lice are wingless insects that are not easily seen and may infect the body, head, or pubic area. Each type of lice can cause severe itching and bites that range from red (body and head lice) to grayish blue (pubic lice). An infestation with lice may be diagnosed with the presence of lice, nits (or eggs), or both. A fine-tooth comb may be needed to assess the hair for lice, and the nits may be easier to see versus the lice itself. Body lice are often found in the seams of clothing and bedding. Pubic lice may require a UV light or a microscope to be seen. Pubic lice may leave feces on the patient’s skin or underwear, which are characterized by dark brown specks. An infestation with lice will require replacing or thoroughly cleaning and drying linens and clothing. Items that are not able to be laundered can be placed in an airtight bag for two weeks to kill the lice. People who have close contact with an infected patient should also treat themselves, including sexual partners (Dinulos, 2023b).

Body lice (pediculosis corporis) live on and lay their eggs on bedding and clothing rather than the skin. The lice will migrate to various areas of the body to feed. Patients who live in crowded areas, have poor hygiene, or are of low socioeconomic status are more at risk of acquiring body lice. The lice spread because of sharing contaminated bedding and clothing. This type of lice can also transmit different types of fevers (Dinulos, 2023b). Treatment includes thoroughly cleaning linens and clothing.

Head lice (pediculosis capitis) are found on the hair and scalp. The lice lay eggs that take about one week to hatch and are called nymphs. It takes another seven days for the nymphs to reach their adult stage. The lice require a blood supply to live and will feed off their host several times a day. If the lice are deprived of blood, they will usually die within one to two days. Hygiene and socioeconomic status have no bearing on head lice. Shampoos that contain permethrin (Acticin), piperonyl butoxide (Red Pediculicide), or lindane (Lindane) are effective for treating head lice. Creams that contain malathion (Ovide) or spinosad (Natroba) suspensions may also be effective. Nits need to be removed with a fine-tooth comb. Treatments must be repeated seven to ten days later to kill any potential newly hatched lice. Ivermectin (Stromectol) may also be used if lice are resistant to medicated shampoos or creams (Dinulos, 2023b).

Pubic lice (pediculosis pubis), often referred to as crabs, infest the hairs of the anal and genital areas but can also infest the thigh, chest, and facial hair. This type of lice may be spread by sexual contact or close contact or by physical objects like linens and clothing. The same shampoos and creams used for head lice are effective for treating pubic lice. In addition, petroleum jelly, physostigmine ointment, fluorescein eye drops, petrolatum salve, and oral ivermectin (Stromectol) are effective for the lice that have infested a patient’s eyelashes (Dinulos, 2023b).

Eczema

The condition eczema (atopic dermatitis) is a part of the atopy family. Atopy means there is a genetic tendency to develop allergic conditions like asthma, eczema, and allergic rhinitis and is associated with a heightened immune response. This rash is characterized by itchy, chronic inflammation of the outer skin layers. In the acute phase, the rash may appear as red, oozing, and crusted areas with occasional blisters present. The chronic phase may have dry, thickened areas caused by scratching and rubbing. The rash may occur in one or more areas in adult patients and can spread to several areas on infants. The rash can vary in intensity, color, and location but is always itchy and triggers scratching, which can cause the skin to break and bleed. Stress, irritation, and dry air also make the itching more intense. Environmental triggers include harsh soaps, excessive bathing or handwashing, sweating, rough fabrics (e.g., wool), or Staphylococcus aureus present on the skin. Allergens like wheat, dairy, and eggs may also be a trigger. Tears in the skin caused by scratching or rubbing can often lead to bacterial infections.

Prevention includes minimizing triggers and managing stress. Treatments include skin care, UV light, corticosteroids, and biologic agents. General skin hygiene includes using soap substitutes, applying moisturizers after bathing, using lukewarm water, and patting skin dry. Antihistamines may also be used to relieve itching. Antibiotics may be needed when the reactions escalate to bacterial infections or for patients who are at risk of developing an infection (Ruenger, 2023). This reaction can be disabling and have long-term emotional effects that may require additional assessment and interventions to promote positive coping and body image.

Seborrheic Dermatitis

The inflammatory skin reaction seborrheic dermatitis affects the scalp and may also be present on the face, around the ears, and occasionally on other areas that have oil glands present. This reaction is more common in infants and adult patients from 30 to 70 years of age. Genetic factors and cold-weather conditions affect the severity and risk of this disorder. The rash is characterized by greasy, yellow scales, pruritus, and dandruff.

Seborrheic dermatitis is triggered by yeast, stress, hormonal changes, harsh detergents or soaps, dry or cold weather, certain medical conditions (e.g., HIV, Parkinson disease), and certain medications (e.g., psoralens [Uvadex] and lithium [Lithobid]). Patients with darker skin may have a darker-colored rash and have lesions around the hairline with possible skin discoloration. Treatments include application of antifungal creams (efinaconazole [Jublia]); corticosteroid creams or solutions (clocortolone pivalate [Cloderm]); calcineurin inhibitors (tacrolimus [Prograf]); antifungal shampoos; and shampoos containing zinc pyrithione (DermaZinc), selenium sulfide (Selsun Blue), and salicylic acid (Baker P&S). Treatment for infants differs by washing with a mild shampoo and applying hydrocortisone cream or fluocinolone oil on the face or into the scalp. Antifungal creams may also be used. Treatment for young children includes using mineral oil, corticosteroid gel, or olive oil to the affected areas (Ruenger, 2023). Treatment often requires repeating until the seborrheic dermatitis is resolved and can be restarted if it returns.

Urticaria

The type I hypersensitivity reaction urticaria (or hives) results from an immunologically mediated antigen-antibody response of mast cells releasing histamine. This reaction is characterized by wheals (or hives) and erythema present after vasodilation and increased vascular permeability. The rash is easily identifiable by a raised, swollen, flesh-colored or red bumps or welts on the skin. This reaction often begins rapidly and may be accompanied by swelling of the face, lips, throat, or airways (angioedema). The wheals can take several weeks to resolve.

The most common triggers include medications, foods, infections, stress, insect bites, and environmental stimuli (e.g., sun, light clothing, sun, heat, cold). Any of the triggers can cause a reaction if injected, inhaled, consumed, or touched. Autoimmune conditions can also trigger urticaria. Any potential or identified trigger must be stopped and removed immediately. Reactions of this type that do not have appropriate intervention may lead to respiratory distress. The airway and breathing must be assessed with this type of reaction, and appropriate intervention must be started immediately if needed. Treatment options also include antihistamines, steroids, or topical antipruritic agents. Epinephrine may also be used for serious reactions. Any identified triggers must be included as part of the patient’s health history. The patient and family should be educated to report this as a reaction to a food, medication, or other environmental trigger, and a medical alert bracelet may also be needed (Ricci et al., 2016).

Acne Vulgaris

Acne is a common inflammatory skin reaction causing pimples, papules, pustules, blackheads, whiteheads, cysts, or abscesses on various areas of the skin. These skin abnormalities vary in size, severity, and deepness into the skin layers. The common skin condition acne vulgaris is caused by bacteria, dead skin cells, or dried sebum that clogs hair follicles and prevents sebum from passing up through the pores (Figure 21.9). Acne triggers include puberty, polycystic ovarian syndrome, pregnancy, menstruation, hormonal disturbances, tight clothing, humidity, sweating, certain medications (e.g., anabolic steroids, corticosteroids), or various skin products (e.g., lotions, makeups, soaps). Identifying triggers can be difficult and may require making small changes at a time to determine the specific cause.

Figure 21.9 There are several types of acne. The most common types are whiteheads, blackheads, pustules, papules, cystic acne, and nodules. (credit: modification of work from Anatomy and Physiology 2e. attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license)

Mild acne includes blackheads, whiteheads, pimples, papules, and pustules and generally does not leave scars unless skin injury occurs when popping or squeezing the pimples. A flesh-colored, small bump with a dark center is a blackhead. A flesh-colored small bump that does not have a dark center is a whitehead. A pimple has a small area of red skin and can be painful or cause discomfort. A pustule is similar to a pimple but contains white or yellow pus. Severe acne is when patients have several blackheads, whiteheads, pimples, pustules, nodules, or deep acne (cystic acne). The cystic acne lesions are usually larger, red, painful, and pus-filled nodules that merge under the skin and often leave scars.

Acne generally lessens in severity by the midtwenties but may appear to those in their forties. This type of skin reaction can cause emotional stress and may require counseling. General care for acne includes washing daily with a mild soap, using water-based cosmetics, and eating a balanced diet low in processed carbohydrates. Inflammatory foods like gluten or dairy may need to be limited because they can cause acne for some individuals. Blackheads and whiteheads can be removed by comedone extraction. This is the use of a comedone extractor by a healthcare professional to incise the pore and then use gentle pressure around the pore opening with a wire loop.

There are also strips available at most pharmacies or grocery retailers for at-home extractions. Other treatment options include tretinoin cream (Retin-A), benzoyl peroxide (Acne-Clear), or antibiotics for blackheads, whiteheads, pimples, and pustules. Isotretinoin (Absorica) is effective for severe acne, and corticosteroids are effective for cystic acne. Other medications like oral contraceptives, spironolactone (Aldactone), and clascoterone (Winlevi) may also be used for hormonal acne. Acne scarring may be treated with a laser, microneedling, dermabrasion, collagen injections, or chemical peels (Keri, 2024).

Psoriasis

The recurring, chronic skin condition psoriasis causes one or more raised areas of red skin patches with silvery scales and a distinct border. Psoriasis is caused by an abnormally high rate of skin cell growth. This skin condition is immune mediated and often occurs because of a genetic predisposition. It can occur anywhere on the body. Various triggers may exacerbate this skin condition, but it is controllable. Flare-ups of psoriasis may be triggered by burns, colds or infections, stress, certain medications, cold weather, obesity, HIV, smoking, and inflammatory foods like gluten. Therapeutic management includes coal tar topical (Balnetar) shampoos, UV light, topical steroids, mineral oil, topical anti-inflammatories, emollient creams, immunosuppressants (e.g., methotrexate [Trexall]), and other medications (e.g., acitretin [Soriatane] and infliximab [Avsola]). Patients who have identifiable triggers may need to engage in lifestyle modifications, such as limiting cold exposure or eliminating inflammatory foods, such as sugar and high-fructose syrups (Das, 2023).

Systemic Lupus Erythematosus

The chronic autoimmune inflammatory disorder systemic lupus erythematosus (SLE) involves connective tissues of the joints, skin, kidneys, mucous membranes, and blood vessel walls. This skin disorder, also known as lupus, can be diagnosed with blood tests or other diagnostic testing. Sudden fever is often the first symptom of this condition. The rash is characterized by round, raised, and reddened areas that can lead to skin loss, scarring, and hair loss. This skin disorder may also include a butterfly-shaped reddened area across the nose and cheeks. Light-exposed areas (e.g., face, scalp) also have clusters of the rash. The rash may be flat or have psoriasis-like characteristics, and those affected may experience painful joints and fatigue. Migraines, mental disorders, epilepsy, and organ dysfunction may also occur. Patients with SLE may experience lung problems (e.g., pleural effusion), heart problems (e.g., pericarditis), enlarged lymph nodes or spleen, kidney failure, decreased blood cells or platelets, gastrointestinal problems (e.g., nausea, pancreatitis), or pregnancy complications (e.g., miscarriage, stillbirth) (Nevares, 2022). People with SLE often also experience Raynaud phenomenon, a condition that causes pale or blue fingers with cold exposure.

Flare-ups of lupus may be triggered by infection, pregnancy, surgery, or sun exposure. Early detection is optimal for a better prognosis and limiting the risks of kidney and other organ damage. Treatment options include hydroxychloroquine (Quineprox), nonsteroid anti-inflammatory drugs, corticosteroid creams, oral corticosteroids, and antimalarial or immunosuppressive medications. People who experience damage to other organs may require a transplant or dialysis, blood clots may need anticoagulants like warfarin (Coumadin), or complications of long-term steroid use may need vitamin D and calcium supplements to aid in preventing osteoporosis. People who have SLE should be closely monitored for diabetes and heart or kidney disease and should be educated on signs and symptoms. Pregnant women with SLE should be closely monitored to avoid flare-ups during pregnancy (Nevares, 2022).

Basal Cell Carcinoma

The most common type of skin cancer is basal cell carcinoma, and it is generally found on the head or neck. This type of skin cancer rarely metastasizes to other parts of the body but does invade and gradually destroy surrounding tissues. Basal cell carcinomas grow slowly and can go unnoticed because of the gradual change. These tumors can grow near the eyes, mouth, nose, or ears. They can be serious but are not usually fatal. Most tumors generally grow into the skin. The lesions are small, shiny bumps that may break open, form a scab, and sometimes bleed or flatten and look like scarring. Although a healthcare provider can easily identify this type of lesion, a biopsy should be performed to confirm the type of cancer. Treatment options include removal of the tumor by curettage and electrodesiccation, cutting it out, or cryosurgery. Topical chemotherapy medications may be applied to the skin. Other options include photodynamic therapy (using lasers and chemicals on the skin) and radiation therapy. Larger areas of basal cell carcinoma may require the MOHS procedure, where layers of the skin are removed and examined for cancer cells until no signs of cancer remain. The healthcare provider (often a dermatologist) may use sutures, skin flaps, or skin grafts to replace the removed skin or refer the patient to a plastic surgeon for closure (Nambudiri, 2024).

Squamous Cell Carcinoma

The second most common type of skin cancer is squamous cell carcinoma that generally develops on sun-exposed areas but can grow where sun exposure is limited. Squamous cell carcinoma is the cancer of squamous cells, keratinocytes, the main epidermal structural cells. This type of skin cancer is more likely with patients who have precancerous growths like actinic keratoses, scarred skin, and chronic mucus membrane or skin sores. This skin cancer generally starts as a red area with a crusted, scaly surface that may turn into a raised, firm wartlike surface. This lesion can become an open sore and grow into the underlying tissues. Biopsy is also best for diagnosing this type of cancer. The prognosis is generally excellent with early intervention. This type of cancer can metastasize and become fatal if not treated in time. Treatment options are similar to basal cell carcinoma but also include using an immune checkpoint inhibitor (e.g., PD-1 inhibitor [cemiplimab]). For patients who have large lesions that have metastasized or spread to the tissues underneath or cannot have surgery, PD-1 inhibitors help the body’s immune system annihilate the cancer (Nambudiri, 2024).

Malignant Melanoma

The most dangerous of the skin cancers is malignant melanoma that originates in the melanocytes. As sunlight increases melanin production, the risk of skin cancer increases. Melanoma metastasizes to distant parts of the body and can often go undetected, making it fatal. Those with undetected melanoma may not be diagnosed until affected organs of the body start displaying symptoms.

Melanoma may begin as a small, pigmented growth in a sun-exposed area or develop in a preexisting mole but can also occur in the mouth, on the genitals or rectal area, in the brain, in nail beds, or in or around the eyes. Risk factors for melanoma include those mentioned for other skin cancers but also include those with previous history of skin cancer, large number of moles, weakened immune system, fair skin, freckles, family history of melanoma, advanced age, and large congenital melanocytic nevus.

Melanomas usually are identifiable by an atypical mole with irregular borders and inconsistent colors. Some may be flat, irregular, brown patches with small black spots or can be raised brown patches with blue, black, red, or white spots. Melanoma can also be red, black, gray, and firm. A biopsy is needed for diagnosis. Nurses should understand the ABCDEs of melanoma and help educate patients on these warning signs (Table 21.6).

Letter	Meaning	Examples
A	Asymmetry = two halves of a mole are not equal	(credit: modification of work "Skin Cancer, Melanoma, Red And Brown Lesion 2" Laurence Meyer, MD, PhD, University of Utah Health Sciences Center/National Cancer Institute, Public Domain)
B	Borders = borders are irregular and seem to blend in or are not oval or round	(credit: modification of work "Skin Cancer, Melanoma, Brown Lesion" by Laurence Meyer, MD, PhD, University of Utah Health Sciences Center/National Cancer Institute, Public Domain)
C	Color = existing mole changes color or moles that have drastically different colors than other moles present on the body	(credit: modification of work "Skin Cancer, Melanoma, Red And Brown Lesion 1" by Laurence Meyer, MD, PhD, University of Utah Health Sciences Center/National Cancer Institute, Public Domain)
D	Diameter = more than ¼ inch (0.6 cm) wide	(credit: modification of work "Skin Cancer, Melanoma, Foot" by Kelly Nelson, MD/National Cancer Institute, Public Domain)
E	Evolution = mole that changes (bleeds, enlarges, becomes tender, itches) or development of a new mole after the age of 30 years	(credit a: modification of work "Common Mole" by National Cancer Institute, Public Domain; credit b: modification of work "Melanoma" by National Cancer Institute, Public Domain)

Table 21.6 The ABCDEs of Melanoma

Treatment options for melanoma are similar to options for the basal cell and squamous cell carcinomas but also include targeted therapy and immunotherapy when the cancer has spread. Targeted therapy consists of medications that attack the cancer cell’s biologic mechanisms and include vemurafenib (Zelboraf) or binimetinib (Mektovi). Patients who have shallow melanomas may be treated with imiquimod cream (Aldara). Chemotherapy may also be needed if the cancer has spread or when no other treatment options are available. Treatment options may be used in combination with other treatments. Radiation therapy is often used when complete removal of the tumor is not achievable or when it has metastasized to the brain (Nambudiri, 2024). If the melanoma is aggressive and has been deemed untreatable or incurable, the patient may need to receive comfort care or hospice care.

Everyone should be screened regularly for skin cancer by a healthcare provider or dermatologist. Nurses should take any opportunity to educate people about sun exposure and ways to help prevent skin cancer. A key point to educate patients on is how to observe changes or unusual skin markings that they should report to their healthcare provider. Additionally, nurses should educate patients about avoiding the sun or seeking shaded areas, especially when the sun’s rays are the strongest (between 10 a.m. and 4 p.m.), wearing sunscreen with an SPF factor of at least thirty or greater, wearing protective clothing (e.g., hats, sunglasses, long sleeves), and avoiding the use of tanning beds (Nambudiri, 2024).